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APIs’ Intermediates
Number Name CAS No. Molecular formula
  Tofacitinib
N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride 1260590-51-9

C13H21Cl2N5

Tofacitinib citrate 540737-29-9

C16H20N6O.C6H8O7

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride 1062580-52-2

C14H24Cl2N2

(2R,3R)-2,3-Bis[(4-methylbenzoyl)oxy]butanedioic acid compd. with (3R,4R)-N,4-dimethyl-1-(phenylmethyl)-3-piperidinamine 477600-71-8

C48H62N4O8

2,4-dichloro-7H-pyrrol-(2,3-d)pyriMidine 90213-66-4

C6H3Cl2N3

4-chloro-7H-pyrollo[2,3d]pyriMidine 3680-69-1

C6H4ClN3

  Neratinib
Neratinib 698387-09-6

C30H29ClN6O3

6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile 848139-78-6

C24H20ClN5O2

N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) 848133-76-6

C14H12ClN3O2

3-chloro-4-(2-pyridinylMethoxy)- BenzenaMine 524955-09-7

C12H11ClN2O

trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7

C6H12ClNO2

  Apalutamide
methyl 1-((3-fluoro-4-(methylcarbamoyl)phenyl)amino) cyclobutanecarboxylate 2227589-23-1

1-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)cyclobutanecarboxylic acid 2227589-22-0

1-Amino-1-cyclobutanecarboxylic acid hydrochloride 98071-16-0

C5H10ClNO2

4-Bromo-2-fluoro-N-methylbenzamide 749927-69-3

C8H7BrFNO

  Elagolix
Elagolix sodium 832720-36-2

C32H29F5N3NaO5

5-(2-fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione 1150560-59-0

C20H15F5N2O3

5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione 830346-48-0

C13H9BrF4N2O2

1-(2-Fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione 830346-47-9

C13H10F4N2O2

2-Fluoro-3-methoxyphenylboronic acid 352303-67-4

C7H8BFO3

1-2-Fluoro-6-trifluoromethylbenzyl urea 830346-46-8

C6H12O2

  EnzalutaMide
N-[3-Fluoro-4-[(MethylaMino)carbonyl]phenyl]-2-Methylalanine 1289942-66-0

C12H15FN2O3

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine methyl ester 1332524-01-2

C13H17FN2O3

  Acalabrutinib
(2S)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-1-Pyrrolidinecarboxylic acid phenylmethyl ester 1420478-88-1

C18H18BrN5O2

4-(Pyridin-2-yl-aminocarbonyl)benzeneboronic acid 850568-25-1

C12H11BN2O3

3-Chloro-2-pyrazinemethanamine hydrochloride 939412-86-9

C5H7Cl2N3

  Abemaciclib
6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole 1231930-33-8

C11H12BrFN2

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 1180132-17-5

C12H20N4

  Roxadustat
Roxadustat 808118-40-3

C19H16N2O5

1 - methyl - 4 - hydroxy - 7 - phenoxy isoquinoline - 3 - methyl formate 1421312-34-6

C18H15NO4

4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester 1455091-10-7

C18H15NO4

  Upadacitinib
Upadacitinib 1310726-60-3

C17H19F3N6O

(3S,4R)-benzyl 3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e] 2095311-51-4

(3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid Dicyclohexylamine Salt 2095311-49-0

2095311-49-0

Carbamic acid,N-[5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazin-2-yl]-, ethyl este 1869118-24-0

N-Tosyl-5-bromo-4,7-diazaindole 1201186-54-0

C13H10BrN3O2S

5-Bromo-4,7-diazaindole 875781-43-4

C6H4BrN3

  Pantoprazole Sodium
2-Chloromethyl-3,4-dimethoxypyridinium chloride 72830-09-2

C8H11Cl2NO2

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 97963-62-7

C8H6F2N2OS

  Baloxavir marboxil
(12aR)-7-(hexyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]Oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione 4-methylbenzenesulfonate 2136287-68-6

Baloxavir marboxil 1985606-14-1

C27H23F2N3O7S

(R)-7-(benzyloxy)- 3,4,12,12a-tetrahydro- 1H-[1,4]oxazino[3,4- c]pyrido[2,1-f][1,2,4]- triazine-6,8-dione 1985607-70-2

7-(Benzyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione 1370250-39-7

7,8-difluoro-6,11-dihydro-Dibenzo[b,e]thiepin-11-ol 1985607-83-7

  Brivaracetam
Brivaracetam 357336-20-0

C33H41N3O10S2

(R)-4-Propyldihydrofuran-2(3H)-one 63095-51-2

C7H12O2

5-Hydroxy-4-propyl-2(5H)-furanone 78920-10-2

C7H10O3

  Other
Bilastine 202189-78-4

C28H37N3O3

L-Alanyl-L-Glutamine 39537-23-0

C8H15N3O4

2-Amino-3,5-Bromo Benzaldehyde 50910-55-9

C7H5Br2NO

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1240948-72-4

C11H6ClFN2

5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde 881674-56-2

C11H8FNO

5-Hydroxy-1-methylpyrazole 33641-15-5

C4H6N2O

(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE 204512-95-8

C4H10ClNO

N-(P-TOLUENESULFONYL)-L-PHENYLALANINE 13505-32-3

C16H17NO4S

3-Hydroxyazetidine hydrochloride 18621-18-6

C3H8ClNO